Monte Carlo Simulation of SARS-CoV-2 Radiation-Induced Inactivation for Vaccine Development

Immunization with an inactivated virus is one of the strategies currently being tested towards developing a SARS-CoV-2 vaccine. One methods used to inactivate viruses exposure high doses ionizing radiation damage their nucleic acids. Although gamma-rays effectively induce lesions in RNA, envelope proteins are also highly damaged process. This turn may alter antigenic properties, affecting capacity adaptive immune response able confer effective protection. Here, we modelled impact sparsely and densely on using Monte Carlo toolkit Geant4-DNA. With realistic 3D target model, calculated expected number spike membrane proteins, as well viral RNA. We show that produce significant protein damage, but charged particles less for same level RNA lesions, because single ion traversal through nuclear sufficient virus. propose accelerated little structural thereby representing new tool vaccines against other enveloped viruses.